Description

(R)-tert-Butyl 1-(Chloromethyl)-5-Hydroxy-1H-Benzo[E]Indole-3(2H)-Carboxylate is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound is specifically designed for the construction of complex molecular architectures, offering a critical stereogenic center and functional handles for further derivatization. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Asymmetric Synthesis: Used in the preparation of complex, enantiomerically pure molecules for research and development.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in mechanism-of-action studies and target identification.
• Material Science Research: Potential monomer or precursor for specialized polymers and advanced organic materials.
• Catalyst Ligand Synthesis: Can be utilized to develop novel chiral ligands for asymmetric catalysis.
• Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-tert-Butyl 1-(Chloromethyl)-5-Hydroxy-1H-Benzo[E]Indole-3(2H)-Carboxylate
CAS No.	130008-89-8
Molecular Formula	C18H20ClNO3
Molecular Weight	333.81 g/mol
Synonyms	(R)-1-(Chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carboxylic acid tert-butyl ester; (R)-tert-Butyl 1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carboxylate; (R)-Boc-1-(Chloromethyl)-5-hydroxy-1,2,3,4-tetrahydrobenzo[e]indole-3-carboxylic acid; tert-Butyl (3R)-1-(chloromethyl)-5-hydroxy-2,3-dihydro-1H-benzo[e]indole-3-carboxylate; (R)-1-(Chloromethyl)-5-hydroxy-1,2,3,4-tetrahydrobenzo[e]indole-3-carboxylic acid tert-butyl ester; (R)-Boc-1-(Chloromethyl)-5-hydroxy-tetrahydrobenzo[e]indole-3-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(Chloromethyl)-5-Hydroxy-1H-Benzo[E]Indole-3(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.