Description

1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid, 2,3,4,9-Tetrahydro-, Ethylester, Monohydrochloride, (S)- is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of complex molecules, particularly those targeting neurological and psychiatric disorders. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of tetrahydro-β-carboline alkaloids and related pharmacologically active compounds.
• Neurological Research: Used in the development of potential therapeutic agents for central nervous system (CNS) disorders, including depression and anxiety.
• Serotonin Receptor Ligand Synthesis: Employed in creating selective ligands for 5-HT (serotonin) receptor subtypes for pharmacological studies.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Contract Research: Used in university and CRO (Contract Research Organization) settings for medicinal chemistry programs and novel drug discovery.

Basic Information

Product Name	1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid, 2,3,4,9-Tetrahydro-, Ethylester, Monohydrochloride, (S)-
CAS No.	129848-93-7
Molecular Formula	C15H18N2O2·HCl
Molecular Weight	294.78 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride; (S)-Ethyl 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride; (S)-Tryptophan ethyl ester hydrochloride (cyclic); (S)-Tetrahydro-β-carboline-3-carboxylic acid ethyl ester hydrochloride; (S)-THBC-OEt·HCl; (S)-9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester, hydrochloride, (3S)-; (S)-Ethyl 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using HPLC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.