Description

1-(tert-Butoxycarbonyl)-5-Fluoroindole is a high-purity, protected indole derivative used as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in the tert-butoxycarbonyl (Boc) protecting group, which safeguards the indole nitrogen during multi-step synthesis, allowing for selective reactions elsewhere on the molecule. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially those containing fluorinated indole scaffolds.
• Agrochemical Research: Used in developing new generation pesticides and herbicides where the 5-fluoroindole moiety imparts specific biological activity.
• Organic Synthesis: Serves as a versatile precursor for creating more complex heterocyclic compounds in academic and industrial R&D settings.
• Peptidomimetics & Bioconjugation: The Boc-protected nitrogen is instrumental in constructing peptide-like molecules and for bioconjugation chemistry.
• Material Science Precursor: Potential use in synthesizing specialty chemicals and advanced organic materials.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-5-Fluoroindole
CAS No.	129822-47-5
Molecular Formula	C₁₃H₁₄FNO₂
Molecular Weight	235.26 g/mol
Synonyms	5-Fluoro-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; 5-Fluoro-1-Boc-indole; 1-Boc-5-fluoroindole; tert-Butyl 5-fluoro-1H-indole-1-carboxylate; N-Boc-5-fluoroindole; 5-Fluoroindole-1-carboxylic acid tert-butyl ester; Boc-5-Fluoroindole; 129822-47-5
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-5-Fluoroindole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay purity and impurity profiles. Our quality commitment aligns with standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.