Description

n-(Boc)-4-Chloroindole CAS NO 129822-46-4 is a high-purity, protected indole derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Peptidomimetics & Bioconjugation: The Boc-protected amine and chloro-substituted indole scaffold are valuable for creating peptide analogs and bioconjugation linkers.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials and advanced polymers.
• Academic & Contract Research: A versatile reagent for methodology development and the synthesis of complex natural product analogs in university and CRO laboratories.
• Scale-up Process Development: Suitable for optimization and kilogram-scale production under GMP or non-GMP conditions for clinical trial material supply.

Basic Information

Product Name	n-(Boc)-4-Chloroindole
CAS No.	129822-46-4
Molecular Formula	C₁₃H₁₄ClNO₂
Molecular Weight	251.71 g/mol
Synonyms	1-Boc-4-Chloroindole; tert-Butyl 4-Chloro-1H-indole-1-carboxylate; 4-Chloro-1H-indole-1-carboxylic acid tert-butyl ester; 4-Chloroindole-1-carboxylic acid tert-butyl ester; N-Boc-4-chloroindole; 1-(tert-Butoxycarbonyl)-4-chloroindole; Boc-4-Cl-indole; 4-Chloro-1-[(2-methylpropan-2-yl)oxycarbonyl]indole
EINECS	Contact for details

Quality Control

Our n-(Boc)-4-Chloroindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting your regulatory and quality assurance requirements for research and commercial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.