Description

4-Fluoro-n-(Boc)-Indole is a high-value, protected indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of a fluorine substituent and a Boc-protected nitrogen, enabling precise molecular construction for complex target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Key building block in the multi-step synthesis of pharmaceutical candidates, especially those targeting central nervous system (CNS) disorders.
• Intermediate for the preparation of fluorinated indole alkaloids and other complex natural product analogs.
• Precursor in the development of novel agrochemicals, where the fluorine atom can enhance biological activity and metabolic stability.
• Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Starting material for the synthesis of specialized ligands and catalysts used in asymmetric synthesis.
• Valuable reagent in academic and industrial R&D for exploring new fluorination and heterocyclic chemistry methodologies.

Basic Information

Product Name	4-Fluoro-n-(Boc)-Indole
CAS No.	129822-45-3
Molecular Formula	C₁₃H₁₄FNO₂
Molecular Weight	235.26 g/mol
Synonyms	1-Boc-4-fluoroindole; 4-Fluoro-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 4-fluoro-1H-indole-1-carboxylate; 4-Fluoroindole-1-carboxylic acid tert-butyl ester; N-Boc-4-fluoroindole; 1-(tert-Butoxycarbonyl)-4-fluoroindole; 4-Fluoro-1-[(2-methyl-2-propanyl)oxycarbonyl]-1H-indole; Boc-4-Fluoroindole
EINECS	Contact for details

Quality Control

Our 4-Fluoro-n-(Boc)-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.