Description

Aesculus Hippocastanum Extract is a standardized botanical extract derived from the horse chestnut tree, known for its key bioactive component, aescin. This high-purity compound is valued for its potent venotonic and anti-inflammatory properties, making it a critical ingredient in advanced formulations. It is primarily utilized by the pharmaceutical, nutraceutical, and cosmeceutical industries for developing products that support vascular health and reduce inflammation.

Application

• Pharmaceutical Formulations: Used as the active pharmaceutical ingredient (API) in oral and topical medications for chronic venous insufficiency (CVI), hemorrhoids, and post-operative edema.
• Dietary Supplements & Nutraceuticals: Incorporated into capsules, tablets, and tinctures aimed at promoting circulatory health and reducing leg swelling and heaviness.
• Cosmeceutical & Skincare Products: A key component in anti-cellulite creams, under-eye serums, and formulations designed to reduce puffiness, dark circles, and improve skin microcirculation.
• Topical Gels & Ointments: Formulated into products for the relief of bruises, sprains, and sports-related injuries due to its anti-edema and anti-inflammatory effects.
• Veterinary Medicine: Applied in treatments for equine and canine limb edema and inflammation.
• Research & Development: Serves as a reference standard and raw material for pharmacological studies on vascular permeability and inflammatory pathways.

Basic Information

Product Name	Aesculus Hippocastanum Extract
CAS No.	129677-95-8
Molecular Formula	Mixture (Primarily C55H86O24 for Aescin)
Molecular Weight	~1131.26 g/mol (for Aescin)
Synonyms	Horse Chestnut Extract; Aescin; Escin; β-Aescin; Escine; Venostasin; Reparil; Venoplant; Venocuran; Venoruton; Hippocastani semen extract; Aesculus Extract
EINECS	Contact for details

Quality Control

Our Aesculus Hippocastanum Extract is produced under strict quality management systems. Each batch is rigorously tested to ensure it meets stringent specifications for aescin content, purity, and the absence of harmful contaminants. We provide comprehensive Certificates of Analysis (COA) detailing assay, heavy metals, residual solvents, and microbiological parameters, supporting compliance with cGMP, ICH Q7, and relevant pharmacopoeial standards (e.g., USP, Ph. Eur.) for botanical extracts.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Fine brownish-yellow powder
Identification (HPLC)	Complies
Assay (Aescin Content)	Min. 95.0% (by HPLC)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 10 ppm
Arsenic (As)	≤ 2 ppm
Total Aerobic Microbial Count	≤ 1000 CFU/g
Total Yeast & Mold Count	≤ 100 CFU/g
E. coli	Absent
Salmonella	Absent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.