Description

n-[4-[2-(2,4-Dimethylphenoxy)Phenyl]-1,3-Thiazol-2-Yl]-1,4,5,6-Tetrahydropyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research and development pipelines. It is primarily sought by pharmaceutical manufacturers and R&D organizations focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: A key scaffold in the production of complex APIs requiring a fused thiazole-tetrahydropyrimidine core structure.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Biochemical Research: Potential use as a reference standard or probe in biochemical assays investigating specific enzyme inhibition or receptor binding.

Basic Information

Product Name	n-[4-[2-(2,4-Dimethylphenoxy)Phenyl]-1,3-Thiazol-2-Yl]-1,4,5,6-Tetrahydropyrimidin-2-Amine
CAS No.	129639-79-8
Molecular Formula	C21H22N4OS
Molecular Weight	378.49 g/mol
Synonyms	1,4,5,6-Tetrahydro-2-[[4-[2-(2,4-dimethylphenoxy)phenyl]-2-thiazolyl]amino]pyrimidine; 2-[[4-[2-(2,4-Dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]amino]-1,4,5,6-tetrahydropyrimidine; Thiazolyl-tetrahydropyrimidinamine derivative; CAS 129639-79-8
EINECS	Contact for details

Quality Control

Our n-[4-[2-(2,4-Dimethylphenoxy)Phenyl]-1,3-Thiazol-2-Yl]-1,4,5,6-Tetrahydropyrimidin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting full specifications are available upon request, and custom synthesis to meet specific purity or impurity profile needs can be arranged.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.