Description

2-[(1,1-Dimethylethyl)Dimethylsilyl]-N,N,5-Trimethyl-1H-Imidazole-1-Sulfonamide-D3 is a deuterated, silyl-protected imidazole sulfonamide derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its primary value lies in its role as a stable, isotopically labeled building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic and neurological pathways. This high-purity specialty chemical is essential for researchers and process chemists in pharmaceutical, agrochemical, and fine chemical industries who require precise molecular tools for deuterium incorporation, tracer studies, and the development of compounds with enhanced metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of deuterated active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to improve metabolic stability and pharmacokinetic profiles.
• Isotope Labeling: Serves as a source of deuterium (D3) for the preparation of internal standards used in Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalytical methods.
• Proteomics & Biochemistry: Potential application in the development of chemical probes and inhibitors for enzyme activity studies.
• Agrochemical Development: Intermediate in the research and synthesis of novel, isotopically labeled pesticides or herbicides.
• Fine Chemical Synthesis: Versatile precursor for constructing complex heterocyclic compounds in custom synthesis and contract manufacturing.

Basic Information

Product Name	2-[(1,1-Dimethylethyl)Dimethylsilyl]-N,N,5-Trimethyl-1H-Imidazole-1-Sulfonamide-D3
CAS No.	129378-56-9
Molecular Formula	C13H26D3N3O2SSi
Molecular Weight	316.55 g/mol
Synonyms	N,N,5-Trimethyl-2-[(tert-butyldimethylsilyl)]-1H-imidazole-1-sulfonamide-D3; 2-(tert-Butyldimethylsilyl)-N,N,5-trimethyl-1H-imidazole-1-sulfonamide-D3; TBDMS-protected imidazole sulfonamide-D3; tert-Butyldimethylsilyl imidazole sulfonamide deuterated; 1H-Imidazole-1-sulfonamide, 2-[(1,1-dimethylethyl)dimethylsilyl]-N,N,5-trimethyl-, D3-labeled; Deuterated TBS-imidazole sulfonamide; Sulfonamide-protected imidazole deuterium standard.
EINECS	Contact for details

Quality Control

Our 2-[(1,1-Dimethylethyl)Dimethylsilyl]-N,N,5-Trimethyl-1H-Imidazole-1-Sulfonamide-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, and deuterium incorporation analysis), HPLC for purity assessment, and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.