Description

n-α-Fmoc-n-γ-Trityl-L-Asparagine n-Carboxyanhydride is a specialized, high-purity amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it enables the controlled, racemization-free incorporation of protected asparagine into complex peptide chains, which is essential for producing research peptides and active pharmaceutical ingredients (APIs) with high fidelity. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the sequential, machine-assisted assembly of peptide sequences, particularly where side-chain protection of asparagine is required.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the synthesis of peptide-based drug candidates and Active Pharmaceutical Ingredients (APIs).
• Research & Development: Used in academic and industrial labs for the discovery and development of novel peptide therapeutics, diagnostics, and probes.
• Synthesis of Protected Peptide Fragments: Employed in solution-phase or hybrid peptide synthesis strategies to create complex, protected segments for fragment condensation.
• Bioconjugation and Labeling: The reactive N-carboxyanhydride (NCA) group and orthogonal protecting groups (Fmoc, Trt) allow for site-specific modifications and labeling of peptides.

Basic Information

Product Name	n-α-Fmoc-n-γ-Trityl-L-Asparagine n-Carboxyanhydride
CAS No.	129288-36-4
Molecular Formula	C39H32N2O6
Molecular Weight	624.69 g/mol
Synonyms	Fmoc-Asp(Trt)-NCA; Nα-Fmoc-Nγ-trityl-L-asparagine N-carboxyanhydride; (S)-4-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-4-(tritylamino)pentanoic anhydride; Fmoc-L-Asparagine(Trt)-NCA; Fmoc-Asparagine(Trityl)-NCA; NCA-Fmoc-Asp(Trt)-OH; Nα-Fmoc-Nβ-trityl-L-asparagine anhydride
EINECS	Contact for details

Quality Control

Our n-α-Fmoc-n-γ-Trityl-L-Asparagine n-Carboxyanhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.