Description

n-Desmethyl Asenapine-D4 CAS NO 128915-56-0 is a deuterium-labeled internal standard critical for the precise quantification of its parent compound in complex biological matrices. This high-purity reference material is essential for ensuring accuracy and reliability in advanced analytical workflows. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and bioanalytical facilities conducting pharmacokinetic, metabolism, and clinical studies.

Application

• Bioanalytical Method Development and Validation: Serves as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) assays.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate measurement of n-Desmethyl Asenapine concentrations in plasma, serum, and other biological fluids.
• Drug Metabolism and Disposition (DMPK) Research: Used to study the metabolic pathways and clearance rates of Asenapine.
• Clinical Trial Support: Provides reliable data for patient monitoring and dose-response analysis during clinical phases.
• Forensic and Anti-Doping Analysis: Supports confirmatory testing in specialized analytical toxicology.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and method transfer protocols.

Basic Information

Product Name	n-Desmethyl Asenapine-D4
CAS No.	128915-56-0
Molecular Formula	C₁₇H₁₂D₄ClNO
Molecular Weight	285.80 g/mol
Synonyms	5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-D4; Asenapine Desmethyl Metabolite-D4; 1-Desmethyl Asenapine-D4; Norasenapine-D4; Asenapine N-Desmethyl-D4; ASN-D4 Metabolite; Deuterated n-Desmethyl Asenapine
EINECS	Contact for details

Quality Control

Our n-Desmethyl Asenapine-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity (typically ≥98%). Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.