Description

Di-p-Chlorobenzyl N,n-Diisopropylphosphoramidite is a specialized organophosphorus compound widely used as a key intermediate in organic synthesis. Its primary value lies in its role as a highly effective phosphitylating agent, crucial for the preparation of phosphoramidites and other nucleotide derivatives. This product is essential for research and production facilities in the pharmaceutical and agrochemical industries, particularly those focused on oligonucleotide synthesis, catalyst development, and the creation of novel phosphorus-containing ligands.

Application

• Oligonucleotide Synthesis: A critical phosphitylating reagent in the solid-phase synthesis of DNA and RNA fragments for research, diagnostics, and therapeutic applications.
• Phosphoramidite Production: Serves as a fundamental building block for manufacturing a wide range of nucleoside and non-nucleoside phosphoramidites.
• Catalyst and Ligand Preparation: Used in the synthesis of chiral and achiral phosphorus-based ligands for asymmetric catalysis and transition metal complexes.
• Agrochemical Intermediates: Employed in the research and development of novel pesticides and herbicides that contain phosphorus moieties.
• Chemical Research: A valuable tool for academic and industrial chemists exploring new phosphorylation methodologies and organophosphorus chemistry.
• Pharmaceutical Intermediates: Facilitates the synthesis of active pharmaceutical ingredients (APIs) that require precise phosphorus incorporation.

Basic Information

Product Name	Di-p-Chlorobenzyl N,n-Diisopropylphosphoramidite
CAS No.	128858-43-5
Molecular Formula	C20H26Cl2NO2P
Molecular Weight	406.30 g/mol
Synonyms	Bis(4-chlorobenzyl) N,N-diisopropylphosphoramidite; Di(4-chlorobenzyl) N,N-diisopropylphosphoramidite; Phosphoramidous acid, P,P-bis[(4-chlorophenyl)methyl]-, N,N-diisopropyl ester; N,N-Diisopropyl-P,P-bis(4-chlorobenzyl)phosphoramidite; Di-p-chlorobenzyl N,N-diisopropylphosphoramidite
EINECS	Contact for details

Quality Control

Every batch of Di-p-Chlorobenzyl N,n-Diisopropylphosphoramidite is manufactured and tested under strict quality management protocols to ensure high purity and consistency. Our products undergo rigorous quality testing, including advanced chromatographic analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications for identity, purity, and moisture content are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
31P NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.