Description

Benzo[B]Thiophen-5-Ylmethanesulfonyl Chloride is a specialized organic sulfonyl chloride derivative, serving as a critical building block in advanced synthetic chemistry. Its primary value lies in its high reactivity as an electrophile, enabling the efficient introduction of the sulfonamide moiety into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Employed in the creation of functional polymers and advanced organic electronic materials.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or modifying biomolecules in proteomics and bio-conjugation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale API development.

Basic Information

Product Name	Benzo[B]Thiophen-5-Ylmethanesulfonyl Chloride
CAS No.	128852-05-1
Molecular Formula	C10H7ClO2S2
Molecular Weight	258.74 g/mol
Synonyms	5-(Chlorosulfonylmethyl)benzo[b]thiophene; 1-Benzothiophen-5-ylmethanesulfonyl chloride; Benzo[b]thiophen-5-ylmethylsulfonyl chloride; 5-(Methanesulfonyl chloride)benzo[b]thiophene; BTMS-Cl; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophen-5-Ylmethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.