Description

n-(2-Bromobenzyloxycarbonyloxy)Succinimide is a specialized active ester reagent used for the introduction of the 2-bromobenzyloxycarbonyl (2-BrZ) protecting group. This compound matters for its high reactivity and selectivity in peptide synthesis and organic transformations, enabling precise chemical modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Protecting group reagent for amines in peptide synthesis, particularly for introducing the 2-bromobenzyloxycarbonyl (2-BrZ) group.
• Key intermediate in the manufacture of pharmaceutical compounds and bioactive molecules.
• Building block for custom chemical synthesis in contract research and development organizations (CROs/CDMOs).
• Reagent for solid-phase peptide synthesis (SPPS) methodologies.
• Used in the preparation of linkers and conjugates for drug delivery systems and prodrugs.
• Facilitates asymmetric synthesis and the construction of chiral intermediates.
• Employed in academic and industrial research for developing new synthetic methodologies.

Basic Information

Product Name	n-(2-Bromobenzyloxycarbonyloxy)Succinimide
CAS No.	128611-93-8
Molecular Formula	C12H10BrNO5
Molecular Weight	328.12 g/mol
Synonyms	2-Bromobenzyloxycarbonyloxy Succinimide; 2-BrZ-OSu; N-[(2-Bromobenzyloxy)carbonyloxy]succinimide; 2-Bromobenzyl N-Succinimidyl Carbonate; 2-Bromobenzyloxycarbonyl Succinimidyl Carbonate; (2-Bromobenzyl) (2,5-dioxopyrrolidin-1-yl) carbonate; NSC 405124; BOC-OSu (2-Bromo analog)
EINECS	Contact for details

Quality Control

Our n-(2-Bromobenzyloxycarbonyloxy)Succinimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.