Description

n-(Cyclopentyloxycarbonyloxy)Succinimide is a specialized active ester reagent widely used in organic synthesis and peptide chemistry. Its primary value lies in its role as a highly effective coupling agent for the introduction of the cyclopentyloxycarbonyl (Cpc) protecting group, particularly for amines. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel active pharmaceutical ingredients (APIs) and complex biomolecules.

Application

• Peptide Synthesis: As a key reagent for introducing the Cpc protecting group onto amino acids during solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate: Used in the multistep synthesis of complex drug candidates, especially those requiring selective amine protection and deprotection strategies.
• Bioconjugation: Facilitates the controlled coupling of bioactive molecules, such as peptides or drug payloads, to carriers like polymers, antibodies, or nanoparticles.
• Organic Synthesis: Employed as a versatile acylating agent for the preparation of amides, carbamates, and other carbonyl derivatives under mild conditions.
• Protecting Group Chemistry: Specifically for the temporary protection of primary and secondary amines, offering stability under various reaction conditions with orthogonal deprotection options.
• Research & Development: A critical tool in medicinal chemistry and process development labs for exploring new synthetic routes and optimizing yields.

Basic Information

Product Name	n-(Cyclopentyloxycarbonyloxy)Succinimide
CAS No.	128595-07-3
Molecular Formula	C10H13NO5
Molecular Weight	227.21 g/mol
Synonyms	N-(Cyclopentyloxycarbonyloxy)succinimide; Cyclopentyloxycarbonyloxy Succinimide; Cpc-OSu; Cpc-O-Su; Cyclopentyloxycarbonyl Succinimidyl Carbonate; Cyclopentyloxycarbonyloxy Succinimidyl Carbonate; N-Succinimidyl Cyclopentyl Carbonate; NSC 330836
EINECS	Contact for details

Quality Control

Our n-(Cyclopentyloxycarbonyloxy)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support regulatory filings with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DMF, DMSO, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.