Description

4-(Trifluoromethyl)-1H-Indole is a versatile fluorinated indole derivative, a key building block in advanced organic synthesis. Its trifluoromethyl group imparts unique electronic and lipophilic properties, making it highly valuable for modulating the biological activity and physicochemical characteristics of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, serving as a critical intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides where the CF3 group enhances metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Fluorine Chemistry & Catalysis: A valuable substrate for studying novel fluorination reactions and developing new catalytic methodologies.
• Ligand & Receptor Probe Development: Employed in medicinal chemistry to create molecular probes for biological target identification and validation.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indole
CAS No.	128562-95-8
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	4-(Trifluoromethyl)indole; 4-Trifluoromethyl-1H-indole; 1H-Indole, 4-(trifluoromethyl)-; 4-CF3-Indole; α,α,α-Trifluoro-p-toluidine, cyclic derivative; 4-(Trifluoromethyl)indole, 95%
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.