Description

(S)-1,2,3,4-Tetrahydro-7-Hydroxyisoquinoline-3-Carboxylic Acid 98% is a high-purity, chiral non-proteinogenic amino acid derivative belonging to the tetrahydroisoquinoline family. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its structural complexity and stereochemical integrity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals. Our supply ensures consistent quality and reliable availability for your most demanding synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) targets.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce rigid, bicyclic structural motifs that can enhance peptide stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a scaffold for constructing compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Biochemical Tool Development: Potential use in designing enzyme inhibitors or probes for studying biological pathways.
• Academic & Industrial R&D: Fundamental research in organic chemistry, heterocyclic chemistry, and the synthesis of natural product analogs.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-7-Hydroxyisoquinoline-3-Carboxylic Acid 98%
CAS No.	128506-12-7
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	(3S)-1,2,3,4-Tetrahydro-7-hydroxy-3-isoquinolinecarboxylic acid; (S)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; L-7-Hydroxy-Tic; (S)-7-Hydroxy-Tic-OH; 7-Hydroxy-L-Tic; (S)-1,2,3,4-Tetrahydro-7-hydroxy-3-isoquinolinecarboxylic acid; (3S)-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of (S)-1,2,3,4-Tetrahydro-7-Hydroxyisoquinoline-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for research and pharmaceutical intermediates. Comprehensive analytical testing, including chiral purity verification, is performed. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.