Description

(S)-6,8-Dibromo-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its value lies in its role as a key building block for the synthesis of complex, biologically active molecules, particularly in the creation of novel therapeutic agents. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require a reliable and high-quality source for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive compounds.
• Asymmetric Synthesis: Serves as a starting material or intermediate in chiral pool syntheses due to its defined (S)-configuration.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying enzyme mechanisms or protein interactions.

Basic Information

Product Name	(S)-6,8-Dibromo-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	128502-57-8
Molecular Formula	C₁₀H₉Br₂NO₃
Molecular Weight	350.99 g/mol
Synonyms	(3S)-6,8-Dibromo-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-6,8-Dibromo-7-hydroxy-3,4-dihydroisoquinoline-3-carboxylic acid; 6,8-Dibromo-7-hydroxy-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; L-6,8-Dibromo-7-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-THIQ-6,8-DiBr-7-OH-3-COOH; 128502-57-8
EINECS	Contact for details

Quality Control

Our production of (S)-6,8-Dibromo-7-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.