Description

1H-Indol-5-Yl Trifluoromethanesulfonate is a high-purity, versatile triflate ester building block essential for advanced organic synthesis. This compound is valued for its excellent leaving group properties, enabling efficient cross-coupling reactions and functional group transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to construct complex indole-based molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting serotonin receptors and neurological pathways.
• Agrochemical Research: Used in creating advanced active ingredients for crop protection products, leveraging the indole scaffold's bioactivity.
• Cross-Coupling Reactions: Serves as a superior electrophile in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings for C-C bond formation.
• Material Science: Employed in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology Probes: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Scale-Up Process Development: Supports route scouting and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Product Name	1H-Indol-5-Yl Trifluoromethanesulfonate
CAS No.	128373-13-7
Molecular Formula	C10H6F3NO3S
Molecular Weight	277.22 g/mol
Synonyms	5-Indolyl Triflate; 5-Trifluoromethanesulfonyloxyindole; Indol-5-yl Triflate; 1H-Indol-5-ol, Trifluoromethanesulfonate; 5-Hydroxyindole Triflate; 5-(Trifluoromethanesulfonyloxy)-1H-indole; 128373-13-7; 5-Indolyl Trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Every batch of 1H-Indol-5-Yl Trifluoromethanesulfonate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.