Description

3-Hydroxy Medetomidine is a key intermediate and active pharmaceutical ingredient (API) metabolite in the synthesis and development of advanced sedative and analgesic agents. Its significance lies in its role as a pharmacologically active derivative of medetomidine, offering a critical building block for research into more selective α-2 adrenergic receptor agonists. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on veterinary medicine, anesthesia, and neuropharmacology.

Application

• Pharmaceutical Intermediate: Primary use as a high-purity synthetic precursor for novel sedative and analgesic drugs.
• Veterinary Medicine Development: Research and production of advanced anesthetic and sedative formulations for animal use.
• Metabolite Reference Standard: Serves as a critical analytical standard in bioanalytical studies and pharmacokinetic research for medetomidine and related compounds.
• Neuropharmacology Research: Used in studies investigating the mechanism of action of α-2 adrenoceptor agonists.
• Active Pharmaceutical Ingredient (API): Potential direct use in the formulation of specialized medicinal products.
• Chemical Synthesis: Valuable building block for medicinal chemists exploring structure-activity relationships in adrenergic agents.

Basic Information

Item	Detail
Product Name	3-Hydroxy Medetomidine
CAS No.	128366-50-7
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	3-Hydroxymedetomidine; Dexmedetomidine Impurity F; (S)-3-Hydroxymedetomidine; 4-[(2,3-Dimethylphenyl)methyl]-1H-imidazole-5-methanol; Medetomidine Metabolite; Dexdomitor Metabolite; Precedex Related Compound; Atipamezole Related Substance
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Medetomidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, identification by spectroscopic methods (IR, NMR, MS), and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) compliant with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.