Description

4-(Trifluoromethylthio)Benzylamine is a versatile organofluorine building block characterized by a benzylamine core functionalized with a trifluoromethylthio group. This compound matters for its unique combination of a reactive primary amine handle and the lipophilic, electron-withdrawing, and metabolically stable trifluoromethylthio moiety, making it a high-value intermediate in advanced synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty chemicals and materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethylthio group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into polymers and advanced materials to impart specific surface properties, such as oleophobicity or chemical resistance.
• Fluorinated Liquid Crystal Precursor: Used in the synthesis of fluorinated components for liquid crystal displays (LCDs).
• Bioconjugation and Probe Synthesis: The amine group allows for conjugation to biomolecules or fluorescent tags, creating chemical probes for biochemical research.

Basic Information

Product Name	4-(Trifluoromethylthio)Benzylamine
CAS No.	128273-56-3
Molecular Formula	C8H8F3NS
Molecular Weight	207.21 g/mol
Synonyms	4-(Trifluoromethylthio)benzylamine; α-Amino-4-(trifluoromethylthio)toluene; (4-(Trifluoromethylthio)phenyl)methanamine; 1-[4-(Trifluoromethylthio)phenyl]methanamine; 4-(Trifluoromethylmercapto)benzylamine; 4-(Trifluoromethylsulfanyl)benzylamine; 4-(SCF3)-Benzylamine; Benzenemethanamine, 4-[(trifluoromethyl)thio]-
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylthio)Benzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.