Description

2-tert-Butyl 1-Ethyl 3,4-Dihydro-6-Hydroxyisoquinoline-1,2(1H)-Dicarboxylate is a high-purity, synthetically valuable isoquinoline derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its complex, functionalized structure makes it indispensable for research and development in medicinal chemistry, enabling the construction of novel compounds with targeted biological activity. This compound is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for the development and optimization of new chemical entities (NCEs) in drug discovery programs.
• Organic Synthesis Reagent: Employed in complex organic transformations, including cyclization and functional group manipulation reactions, due to its reactive ester and hydroxyl groups.
• Precursor for Alkaloid Analogues: Serves as a starting material for the synthesis of tetrahydroisoquinoline-based alkaloid analogues with potential biological activity.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	2-tert-Butyl 1-Ethyl 3,4-Dihydro-6-Hydroxyisoquinoline-1,2(1H)-Dicarboxylate
CAS No.	128073-49-4
Molecular Formula	C₁₉H₂₅NO₅
Molecular Weight	347.41 g/mol
Synonyms	1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-6-hydroxy-, 1-ethyl 2-(1,1-dimethylethyl) ester; 1-Ethyl 2-tert-butyl 3,4-dihydro-6-hydroxy-1,2(1H)-isoquinolinedicarboxylate; 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1,2-dicarboxylic acid 1-ethyl 2-tert-butyl ester; tert-Butyl ethyl 6-hydroxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate; Ethyl tert-butyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1,2-dicarboxylate; 128073-49-4; Advanced Pharmaceutical Intermediate (API) 128073-49-4.
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl 1-Ethyl 3,4-Dihydro-6-Hydroxyisoquinoline-1,2(1H)-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.