Description

3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-6-Hydroxy-, Ethyl Ester, Hydrochloride (1:1) is a high-purity synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a versatile building block for constructing complex nitrogen-containing heterocycles, which are core structures in many active pharmaceutical ingredients. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on developing new therapeutic agents and crop protection products. We supply this material with a commitment to consistent quality and reliable global supply chain support.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel isoquinoline-based drug candidates, including potential central nervous system (CNS) agents and antimicrobials.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its heterocyclic scaffold for bioactivity.
• Chemical Synthesis Building Block: Employed in academic and industrial R&D for constructing complex molecular architectures in medicinal chemistry programs.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal complexation studies.
• Reference Standard: Supplied as a high-purity compound for analytical method development, validation, and quality control in manufacturing processes.

Basic Information

Product Name	3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-6-Hydroxy-, Ethyl Ester, Hydrochloride (1:1)
CAS No.	128073-39-2
Molecular Formula	C₁₃H₁₅NO₃·HCl
Molecular Weight	269.72 g/mol (Free base: 233.26 g/mol)
Synonyms	6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ethyl ester hydrochloride; Ethyl 6-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride; 1,2,3,4-Tetrahydro-6-hydroxy-3-isoquinolinecarboxylic acid ethyl ester hydrochloride; 6-Hydroxy-THIQ-3-ethyl carboxylate HCl; 128073-39-2; 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ethyl ester HCl salt
EINECS	Contact for details

Quality Control

Our 3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-6-Hydroxy-, Ethyl Ester, Hydrochloride (1:1) is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the high standards of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.