Description

[trans-3-(Benzyloxy)Cyclobutyl]Methanol is a versatile cyclobutane derivative featuring a benzyl-protected hydroxyl group and a primary alcohol functionality, making it a valuable chiral building block in advanced organic synthesis. Its rigid cyclobutane core and orthogonal protecting groups are critical for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including protease inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used in constructing novel pesticide and herbicide molecules where the cyclobutane scaffold contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or nitrogen-based ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of monomers or cross-linkers for advanced polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways due to its modifiable handles.
• Academic & Process R&D: A valuable reagent for methodological studies in organic chemistry and scale-up process optimization.

Basic Information

Product Name	[trans-3-(Benzyloxy)Cyclobutyl]Methanol
CAS No.	128041-57-6
Molecular Formula	C12H16O2
Molecular Weight	192.26 g/mol
Synonyms	(1r,3r)-3-(Benzyloxy)cyclobutylmethanol; trans-3-(Benzyloxy)cyclobutanemethanol; (1R,3R)-3-(Phenylmethoxy)cyclobutanemethanol; 3-(Benzyloxy)cyclobutylmethanol (trans-); Cyclobutanemethanol, 3-(phenylmethoxy)-, (1R,3R)-rel-; (rel)-(1R,3R)-3-(Benzyloxy)cyclobutyl]methanol
EINECS	Contact for details

Quality Control

Our [trans-3-(Benzyloxy)Cyclobutyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.