Description

5-(Trifluoromethyl)-2-Thiophenecarboxylic Acid is a high-value fluorinated heterocyclic building block characterized by its thiophene core and electron-withdrawing trifluoromethyl group. This compound is essential for introducing specific steric and electronic properties into advanced molecular architectures, enabling the development of materials with enhanced performance. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries for synthesizing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3-thiophene moiety can improve metabolic stability and bioavailability.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs), leveraging its unique coordination properties.
• Fluorinated Liquid Crystal Research: Acts as a core component in the development of novel fluorinated liquid crystals for display technologies.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-(Trifluoromethyl)-2-Thiophenecarboxylic Acid
CAS No.	128009-32-5
Molecular Formula	C6H3F3O2S
Molecular Weight	196.15 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)thiophene-2-carboxylic acid; α-Thenyl-α,α,α-trifluoro-o-toluic acid; 2-Carboxy-5-(trifluoromethyl)thiophene; 5-Trifluoromethyl-2-thiophenecarboxylic acid; 5-Trifluoromethylthiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-2-Thiophenecarboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) are provided with every shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.