Description

tert-Butyl 6-Formyl-1H-Indole-1-Carboxylate is a high-purity, protected indole derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a reactive formyl group on the indole scaffold while the nitrogen is protected by the acid-labile Boc group, enabling precise and sequential chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the indole core's biological activity.
• Material Science: Serves as a precursor for functionalized organic materials and ligands for catalytic systems.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions and heterocycle functionalization.
• Peptidomimetics: Employed in the design and synthesis of peptidomimetic compounds where the indole moiety mimics natural amino acid side chains.

Basic Information

Product Name	tert-Butyl 6-Formyl-1H-Indole-1-Carboxylate
CAS No.	127956-28-9
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	1-Boc-6-formylindole; 1-(tert-Butoxycarbonyl)-6-formyl-1H-indole; 6-Formyl-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-formylindole-1-carboxylate; 6-Formylindole-1-carboxylic acid tert-butyl ester; Boc-6-formylindole; 1H-Indole-1-carboxylic acid, 6-formyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Formyl-1H-Indole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.