Description

6-(Difluoromethyl)Indole is a high-value, fluorinated indole derivative serving as a critical building block in advanced organic synthesis. Its unique difluoromethyl group imparts desirable metabolic stability and lipophilicity, making it a sought-after intermediate for pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group enhances biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialized organic electronic materials and functional dyes.
• Fluorine Chemistry Research: Serves as a model compound for studying the effects of fluorination on indole reactivity and physical properties in academic and industrial R&D settings.
• Ligand and Catalyst Development: Utilized to create novel ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	6-(Difluoromethyl)Indole
CAS No.	127956-27-8
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	6-(Difluoromethyl)-1H-indole; 1H-Indole, 6-(difluoromethyl)-; Indole, 6-(difluoromethyl)-; 6-Difluoromethylindole; 6-(Difluoromethyl)-indole; 6-Difluoromethyl-1H-indole; 6-(Difluoromethyl)indole; 6-Difluoromethyl indole
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to meet exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.