Description

1-Boc-6-Methylindole is a protected indole derivative of significant importance in synthetic organic chemistry. This compound serves as a versatile and crucial building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the indole scaffold is a core structural motif.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, to introduce functionalized indole units.
• Material Science Precursor: Acts as a starting material for the synthesis of organic semiconductors and photoluminescent compounds.
• Peptidomimetics & Alkaloid Synthesis: Facilitates the construction of complex natural product analogs and constrained peptide structures.
• Chemical Biology Probes: Useful for creating labeled compounds and molecular probes for studying biological systems.

Basic Information

Product Name	1-Boc-6-Methylindole
CAS No.	127956-24-5
Molecular Formula	C₁₄H₁₇NO₂
Molecular Weight	231.29 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-6-methylindole; 6-Methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 6-methyl-1H-indole-1-carboxylate; 1-Boc-6-methyl-1H-indole; Boc-6-methylindole; N-Boc-6-methylindole; 6-Methylindole-1-carboxylic acid tert-butyl ester; 1-tert-Butoxycarbonyl-6-methylindole
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Methylindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.