Description

R-6-Bromo-α-(1,1-Dimethylethyl)-2-Pyridinemethanol is a specialized brominated pyridine derivative that serves as a crucial chiral building block and intermediate in advanced organic synthesis. Its unique sterically hindered structure, featuring a tert-butyl group adjacent to the bromine-substituted pyridine ring, makes it highly valuable for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, including potential drug candidates and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the synthesis of advanced pesticides and herbicides, where its bromopyridine core can be leveraged to create compounds with specific biological activity.
• Ligand Precursor: Serves as a precursor for the synthesis of specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of novel organic electronic materials and functional polymers due to its electron-deficient pyridine ring system.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and tool compounds in biochemical and pharmacological research.

Basic Information

Product Name	R-6-Bromo-α-(1,1-Dimethylethyl)-2-Pyridinemethanol
CAS No.	127912-58-7
Molecular Formula	C10H14BrNO
Molecular Weight	244.13 g/mol
Synonyms	(R)-6-Bromo-α-(tert-butyl)-2-pyridinemethanol; (R)-6-Bromo-α-(1,1-dimethylethyl)-2-pyridinemethanol; (R)-2-(tert-Butyl)-6-bromo-2-pyridinemethanol; (R)-α-(tert-Butyl)-6-bromo-2-pyridinemethanol; (R)-6-Bromo-2-(2-hydroxy-2-methylpropyl)pyridine; (R)-6-Bromo-α-tert-butyl-2-pyridinemethanol; (R)-6-Bromo-2-(1-hydroxy-1-methylethyl)pyridine; R-6-Bromo-α-tert-butyl-2-pyridinemethanol
EINECS	Contact for details

Quality Control

Our R-6-Bromo-α-(1,1-Dimethylethyl)-2-Pyridinemethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.