Description

(R)-1-[3-(Trifluoromethyl)Phenyl]Ethanol is a high-purity chiral alcohol building block of significant importance in advanced organic synthesis. Its value lies in the combination of a stereogenic center and a trifluoromethylphenyl group, which is crucial for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in asymmetric synthesis and as a key intermediate for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective reactions to produce enantiomerically pure compounds.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in transition metal catalysis.
• Agrochemical Research: Employed in the development of advanced pesticides and herbicides where the chiral center influences biological efficacy.
• Material Science: A building block for specialty polymers and liquid crystals, where the trifluoromethyl group imparts unique stability and optical properties.
• Flavor and Fragrance Industry: Potential use in the synthesis of chiral aroma chemicals and flavor enhancers.

Basic Information

Product Name	(R)-1-[3-(Trifluoromethyl)Phenyl]Ethanol
CAS No.	127852-24-8
Molecular Formula	C9H9F3O
Molecular Weight	190.16 g/mol
Synonyms	(R)-1-(3-Trifluoromethylphenyl)ethanol; (R)-α-(3-Trifluoromethylphenyl)ethanol; (R)-3'-(Trifluoromethyl)phenethyl alcohol; (R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-ol; (R)-m-(Trifluoromethyl)phenethyl alcohol; (R)-1-(m-Trifluoromethylphenyl)ethanol; (R)-HMPE (abbreviation); (R)-TMPE
EINECS	Contact for details

Quality Control

Our production of (R)-1-[3-(Trifluoromethyl)Phenyl]Ethanol adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles, supporting compliance with cGMP and ISO 9001 standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen) for prolonged storage to prevent oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.