Description

Diethyl α-Hydroxy-α-(1-Methylindol-3-Yl)-Malonate is a specialized indole-based malonate ester derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. This compound matters for its role as a versatile building block, enabling the construction of complex molecular architectures with high precision. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indole scaffold for biological activity.
• Fine Chemical Synthesis: Serves as a precursor for creating specialty chemicals, dyes, and advanced materials.
• Academic & R&D: Employed in university and corporate research laboratories for methodological studies and novel compound library generation.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of high-value target molecules.

Basic Information

Item	Detail
Product Name	Diethyl α-Hydroxy-α-(1-Methylindol-3-Yl)-Malonate
CAS No.	127744-44-9
Molecular Formula	C₁₆H₁₉NO₅
Molecular Weight	305.33 g/mol
Synonyms	Diethyl 2-hydroxy-2-(1-methyl-1H-indol-3-yl)malonate; Diethyl (hydroxy)(1-methyl-1H-indol-3-yl)propanedioate; α-Hydroxy-α-(1-methylindol-3-yl)malonic acid diethyl ester; 1-Methyl-3-(diethoxycarbonyl)(hydroxy)methylindole; 3-(1,1-Diethoxycarbonyl-1-hydroxy-methyl)-1-methylindole; Hydroxy(1-methyl-1H-indol-3-yl)malonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl α-Hydroxy-α-(1-Methylindol-3-Yl)-Malonate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.