Description

5-Fluoro-3-(1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole CAS NO 127626-06-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole-tetrahydropyridine fused structure. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and neurological disorder therapeutics. Our supply ensures consistent quality and reliable availability for your development and scale-up processes.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of novel drug candidates targeting neurological receptors.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• CNS Drug Development: Serves as a core scaffold for compounds being investigated for the treatment of disorders like depression, anxiety, and schizophrenia.
• Biochemical Research: Employed as a reference standard or probe in pharmacological assays and receptor binding studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	5-Fluoro-3-(1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole
CAS No.	127626-06-6
Molecular Formula	C13H13FN2
Molecular Weight	216.26 g/mol
Synonyms	5-Fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole; 3-(1,2,3,6-Tetrahydro-4-pyridinyl)-5-fluoro-1H-indole; 5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole; 5-Fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)indole; 5-Fluoro-3-(4-piperidinylidene)indole (tautomeric form); 127626-06-6; 5-Fluoro-3-(1,2,3,6-tetrahydro-4-pyridyl)indole
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-3-(1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support your regulatory filings, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC. Certificates of Analysis (COA) detailing batch-specific results are available for all shipments. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.