Description

3-((tert-Butyldiphenylsilyl)Oxy)Propan-1-Ol is a high-value organosilicon-protected alcohol intermediate, essential for advanced organic synthesis. This compound matters because it provides a robust, orthogonal protecting group for primary alcohols, enabling complex multi-step reactions in sensitive molecule construction. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need it for the precise synthesis of APIs, natural products, and novel materials where selective deprotection is critical.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug candidates.
• Peptide & Oligonucleotide Synthesis: Used to protect hydroxyl groups on nucleosides, sugars, and amino acid side chains during solid-phase and solution-phase synthesis.
• Natural Product & Total Synthesis: Employed in the construction of complex polyketides, macrolides, and other natural products requiring temporary hydroxyl protection under a variety of reaction conditions.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators with improved selectivity and stability.
• Material Science Precursor: Serves as a functional monomer or cross-linking agent in the development of specialty silicones, polymers, and dendrimers with tailored properties.
• Asymmetric Catalysis Ligand Synthesis: Used to prepare chiral ligands and auxiliaries for enantioselective transformations in fine chemical production.

Basic Information

Product Name	3-((tert-Butyldiphenylsilyl)Oxy)Propan-1-Ol
CAS No.	127047-71-6
Molecular Formula	C19H26O2Si
Molecular Weight	314.50 g/mol
Synonyms	3-[(tert-Butyldiphenylsilyl)oxy]-1-propanol; 3-(tert-Butyldiphenylsiloxy)-1-propanol; 1-Propanol, 3-[(1,1-dimethylethyl)diphenylsilyl]oxy]-; 3-(TBDPSO)-1-propanol; 3-Hydroxypropyl tert-butyldiphenylsilyl ether; TBDPS-protected 3-hydroxypropanol; 3-O-TBDPS-propanol; TBDPS-O-(CH2)3-OH
EINECS	Contact for details

Quality Control

Our 3-((tert-Butyldiphenylsilyl)Oxy)Propan-1-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material meeting custom specifications for advanced synthetic programs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.