Description

1-((R)-2-Chloro-1-Methylene-Propyl)-2,4-Difluoro-Benzene CAS NO 126917-44-0 is a chiral, fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, combining a reactive chloromethylene group with difluorobenzene and a stereogenic center, enabling the construction of complex, biologically active molecules. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, where its fluorine atoms and defined stereochemistry are critical for modulating potency, metabolic stability, and selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis, leveraging its stereogenic center to induce chirality in reaction products.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with unique optical or electronic properties.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on the synthesis and reactivity of fluorinated organic molecules.

Basic Information

Item	Detail
Product Name	1-((R)-2-Chloro-1-Methylene-Propyl)-2,4-Difluoro-Benzene
CAS No.	126917-44-0
Molecular Formula	C10H9ClF2
Molecular Weight	202.63 g/mol
Synonyms	(R)-1-(2-Chloro-1-methylenepropyl)-2,4-difluorobenzene; 2,4-Difluoro-(R)-α-(chloromethyl)styrene; (R)-2-Chloro-1-(2,4-difluorophenyl)prop-1-ene; 1-(2-Chloro-1-methylenepropyl)-2,4-difluorobenzene (R-enantiomer); 126917-44-0; Benzene, 1-((1R)-2-chloro-1-methylenepropyl)-2,4-difluoro-
EINECS	Contact for details

Quality Control

Our production of 1-((R)-2-Chloro-1-Methylene-Propyl)-2,4-Difluoro-Benzene adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/Chiral GC), identity confirmation (IR, NMR), and quantification of key impurities (GC/HPLC). A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and full specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong alkali and fluoride ions; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.