Description

4-Methyl-2-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid is a high-value heterocyclic building block characterized by its trifluoromethyl-substituted thiazole core. This compound is essential for medicinal chemistry and agrochemical research, where its unique structure imparts desirable physicochemical properties to target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in areas requiring fluorine-containing motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the thiazole and trifluoromethyl groups contribute to biological activity.
• Material Science Research: Serves as a precursor for functional materials, such as liquid crystals or organic electronic components, due to its rigid, aromatic structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for clients worldwide.

Basic Information

Product Name	4-Methyl-2-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid
CAS No.	126889-06-3
Molecular Formula	C6H4F3NO2S
Molecular Weight	211.16 g/mol
Synonyms	5-Thiazolecarboxylic acid, 4-methyl-2-(trifluoromethyl)-; 2-Trifluoromethyl-4-methyl-1,3-thiazole-5-carboxylic acid; 4-Methyl-2-trifluoromethylthiazole-5-carboxylic acid; 4-Methyl-2-(trifluoromethyl)-5-thiazolecarboxylic acid; 2-(Trifluoromethyl)-4-methyl-1,3-thiazole-5-carboxylic acid; 126889-06-3; 4-Methyl-2-(trifluoromethyl)thiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, and we support audits for cGMP, ISO, and other relevant regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥98.0% / ≥99.0% (High Purity Grades)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.