Description

Dl-Leucine-D10-n-Fmoc CAS NO 126727-03-5 is a deuterium-labeled, Fmoc-protected derivative of the amino acid leucine, serving as a critical building block in advanced organic synthesis. This high-purity, isotopically labeled compound is essential for applications requiring precise molecular tracking and structural integrity. It is primarily utilized by research institutions and pharmaceutical developers engaged in peptide synthesis, metabolic studies, and the development of labeled standards for mass spectrometry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected, deuterated amino acid for the controlled assembly of peptides with isotopic labels.
• Isotopic Labeling & Tracer Studies: For use in metabolic pathway analysis, pharmacokinetic studies, and drug metabolism research (DMPK) utilizing mass spectrometry.
• Internal Standard Development: A key precursor for synthesizing quantitative internal standards for LC-MS/MS and GC-MS analysis, ensuring accurate bioanalytical measurements.
• Pharmaceutical Research: In the discovery and development of novel peptide-based therapeutics and diagnostic agents.
• Biochemical Research: For probing protein structure, function, and dynamics through isotopic labeling techniques.
• Proteomics & Biomarker Discovery: To create labeled peptides for relative and absolute quantification (SILAC, AQUA) in complex biological samples.

Basic Information

Product Name	Dl-Leucine-D10-n-Fmoc
CAS No.	126727-03-5
Molecular Formula	C₂₁H₁₁D₁₀NO₄
Molecular Weight	369.46 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-leucine-d10; Fmoc-DL-leucine-d10; (RS)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methyl-d10-pentanoic acid; Deuterated Fmoc-DL-leucine; DL-Leucine-d10, N-Fmoc derivative; Fmoc-DL-leu-d10; N-α-Fmoc-DL-leucine-d10; Isotopically labeled Fmoc-leucine
EINECS	Contact for details

Quality Control

Our Dl-Leucine-D10-n-Fmoc is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (HPLC), isotopic purity (NMR/MS), and chiral purity. We adhere to cGMP principles for advanced research chemicals, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and analytical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.