Description

Talwin Nx is a pharmaceutical-grade analgesic compound, a combination product primarily containing pentazocine and naloxone. This formulation is specifically engineered to provide effective pain management while incorporating an abuse-deterrent mechanism, making it a critical component in controlled therapeutic regimens. It is essential for pharmaceutical manufacturers and research institutions developing or producing schedule IV narcotic analgesic medications for the treatment of moderate to severe pain.

Application

• Pharmaceutical Manufacturing: Primary use in the formulation of oral analgesic tablets for pain relief.
• Abuse-Deterrent Medication Production: Key ingredient in combination products designed to reduce the potential for misuse via injection.
• Clinical Research: Used in studies focusing on opioid agonist-antagonist pharmacology and pain management protocols.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories in drug testing and verification.
• Generic Drug Development: Critical for companies developing bioequivalent versions of branded pentazocine/naloxone combination drugs.

Basic Information

Item	Detail
Product Name	Talwin Nx
CAS No.	126663-39-6
Molecular Formula	C19H27NO · C20H23NO4 · xH2O
Molecular Weight	Contact for details (combination product)
Synonyms	Pentazocine and Naloxone Hydrochlorides; Pentazocine/Naloxone; Talwin NX; Naloxone Hydrochloride and Pentazocine Hydrochloride; WIN 34,551; CPH-45-NX; (-)-17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one compound with 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol
EINECS	Contact for details

Quality Control

Our Talwin Nx is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical active ingredients. Every batch is tested to ensure identity, purity, potency, and the absence of specified impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from advanced analytical techniques including HPLC, GC, and spectroscopy to confirm compliance with in-house specifications and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (Pentazocine HCl)	98.0% - 102.0% (on anhydrous basis)
Assay (Naloxone HCl)	90.0% - 110.0% of labeled claim
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.