Description

(R)-3,4-Difluoro-α-Methylbenzyl Alcohol is a high-value, optically active chiral building block. This compound matters as a critical intermediate for the synthesis of advanced pharmaceutical active ingredients and agrochemicals, where its specific stereochemistry and fluorine substitution pattern are essential for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel, potent molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the difluoro and chiral alcohol motifs enhance efficacy and selectivity.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and organometallic complexes.
• Material Science Research: Intermediate for creating specialty monomers and polymers with unique optical or electronic properties.
• Fine Chemical Production: Serves as a precursor for other high-value fluorinated and chiral fine chemicals.

Basic Information

Product Name	(R)-3,4-Difluoro-α-Methylbenzyl Alcohol
CAS No.	126534-41-6
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	(R)-1-(3,4-Difluorophenyl)ethanol; (R)-α-Methyl-3,4-difluorobenzyl Alcohol; (R)-3,4-Difluoro-α-methylbenzenemethanol; (1R)-1-(3,4-Difluorophenyl)ethan-1-ol; (R)-(-)-1-(3,4-Difluorophenyl)ethyl Alcohol; (R)-3,4-DFMBA; (R)-3,4-Difluorophenethyl Alcohol (common misnomer); (R)-3,4-Difluoro-1-phenylethanol
EINECS	Contact for details

Quality Control

Our (R)-3,4-Difluoro-α-Methylbenzyl Alcohol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, GC, and NMR, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.