Description

Tipelukast is a potent and selective leukotriene receptor antagonist (LTRA) with the CAS registry number 125961-82-2. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action against inflammatory pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for respiratory and inflammatory conditions.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-asthma and anti-allergy medications.
• Biochemical Assays: Used as a selective ligand in in vitro studies to investigate leukotriene D4 (LTD4) receptor binding and function.
• Mechanism of Action Studies: Employed in preclinical research to elucidate the role of cysteinyl leukotrienes in inflammatory diseases such as asthma, allergic rhinitis, and atopic dermatitis.
• Drug Discovery Programs: Acts as a critical chemical entity for structure-activity relationship (SAR) studies aimed at developing next-generation LTRAs with improved efficacy and safety profiles.
• Academic Research: Utilized in university and institutional labs for pharmacological studies focused on airway hyperresponsiveness and inflammation models.

Basic Information

Product Name	Tipelukast
CAS No.	125961-82-2
Molecular Formula	C31H33N3O6S
Molecular Weight	575.68 g/mol
Synonyms	Tipelukast; 4-[[4-[[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-2,3,5,6-tetrafluorophenyl]methoxy]-3-methoxybenzoic Acid; ONO-RS-411; RS-411; 125961-82-2; Leukotriene D4 receptor antagonist ONO-RS-411.
EINECS	Contact for details

Quality Control

Our Tipelukast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS), purity assessment by HPLC, and control of specified impurities. We provide full traceability and a Certificate of Analysis (COA) with every shipment to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.