Description

n-(Trimethylamine-Borane-Carbonyl)Proline Methyl Ester is a specialized organoboron compound that serves as a valuable building block in advanced synthetic chemistry. Its unique structure, combining a proline derivative with a trimethylamine-borane complex, makes it a versatile reagent for the synthesis of complex molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists working on peptide mimetics, boron neutron capture therapy (BNCT) agents, and novel drug candidates requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting protease inhibition.
• Boron Neutron Capture Therapy (BNCT): Serves as a sophisticated boron carrier for the development of next-generation cancer therapeutics.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective reactions to construct complex molecular architectures.
• Peptidomimetic Research: Integral for creating proline-based peptide analogs and conformationally constrained scaffolds in drug discovery.
• Organometallic & Catalysis: Acts as a ligand precursor or a source of stabilized borane for catalytic applications and material science.
• Academic & R&D: Employed in research laboratories for methodological development and exploring new chemical spaces.

Basic Information

Item	Detail
Product Name	n-(Trimethylamine-Borane-Carbonyl)Proline Methyl Ester
CAS No.	125893-97-2
Molecular Formula	C11H21BN2O3
Molecular Weight	240.11 g/mol
Synonyms	L-Proline, 1-[(trimethylamine)carbonylborane]-, methyl ester; Methyl 1-[(trimethylamine)carbonylborane]-L-prolinate; Trimethylamine-Carbonylborane Complex of Methyl L-Prolinate; Proline Methyl Ester Trimethylamine Borane Carbonyl Complex; TMAB-Carbonyl-Proline-OMe; N-(TMA-Borane-Carbonyl)-L-Proline Methyl Ester; (S)-1-((Trimethylamine-κN)carbonylboraneyl)pyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our n-(Trimethylamine-Borane-Carbonyl)Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.