Description

1,1,1-Trifluoro-3-Thiophen-3-Yl-Propan-2-One is a high-value fluorinated organic building block characterized by its trifluoromethyl ketone and thiophene heterocycle. This compound matters for its unique reactivity profile, serving as a versatile synthon for introducing fluorine and sulfur-containing motifs into complex molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring advanced functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the thiophene moiety for bioactivity and the fluorine atoms for environmental persistence and efficacy.
• Material Science Research: Employed as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials with tailored optical and electronic properties.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors and activity-based probes, where the ketone group can act as an electrophilic trap for nucleophilic amino acids.
• Fluorine Chemistry Research: An important substrate for studying novel fluorination reactions and the stereoelectronic effects of the CF3 group adjacent to a carbonyl.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	1,1,1-Trifluoro-3-Thiophen-3-Yl-Propan-2-One
CAS No.	125774-46-1
Molecular Formula	C8H5F3OS
Molecular Weight	206.19 g/mol
Synonyms	3-(3-Thienyl)-1,1,1-trifluoro-2-propanone; 1,1,1-Trifluoro-3-(3-thienyl)propan-2-one; 3-Thiophen-3-yl-1,1,1-trifluoropropan-2-one; 3-(3-Thienyl)-1,1,1-trifluoroacetone; 1,1,1-Trifluoro-3-(thiophen-3-yl)propan-2-one; 3-Thien-3-yl-1,1,1-trifluoro-2-propanone; TFTP; 3-Thienyl Trifluoromethyl Ketone
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-Thiophen-3-Yl-Propan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure consistent high quality and reliable performance in your synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.