Description

(1R,3S)-3-[[(E)-Tetrahydro-2-Oxothiophene-3-Ylidene]Methyl]-2,2-Dimethylcyclopropanecarboxylic Acid Benzyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropane and thiophene-derived structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for its role in constructing molecules with specific stereochemistry and biological activity.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the production of complex APIs, especially those targeting neurological and metabolic disorders.
• Agrochemical Research & Development: Used in the synthesis of novel pesticides and herbicides, leveraging its unique structural motifs for bioactivity.
• Material Science Precursor: Acts as a starting material for the development of specialty polymers and advanced organic electronic materials.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Utilized in developing and optimizing scalable synthetic routes for commercial manufacturing.

Basic Information

Product Name	(1R,3S)-3-[[(E)-Tetrahydro-2-Oxothiophene-3-Ylidene]Methyl]-2,2-Dimethylcyclopropanecarboxylic Acid Benzyl Ester
CAS No.	125603-72-7
Molecular Formula	C19H22O3S
Molecular Weight	330.44 g/mol
Synonyms	Benzyl (1R,3S)-3-[(E)-2-oxotetrahydrothiophen-3-ylidene]methyl-2,2-dimethylcyclopropane-1-carboxylate; (1R-cis)-3-[[(E)-Tetrahydro-2-oxo-3-thienylidene]methyl]-2,2-dimethylcyclopropanecarboxylic Acid Phenylmethyl Ester; Chrysanthemic acid derivative benzyl ester; 2,2-Dimethyl-3-(2-oxotetrahydrothiophen-3-ylidenemethyl)cyclopropanecarboxylic acid benzyl ester; (1R,3S)-Chrysanthemic acid benzyl ester thiophene derivative.
EINECS	Contact for details

Quality Control

Our production of (1R,3S)-3-[[(E)-Tetrahydro-2-Oxothiophene-3-Ylidene]Methyl]-2,2-Dimethylcyclopropanecarboxylic Acid Benzyl Ester adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under inert atmosphere where appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.