Description

m-Peg6-Bromide CAS NO 125562-29-0 is a high-purity, functionalized polyethylene glycol derivative featuring a terminal bromo group, designed for advanced chemical synthesis and bioconjugation. This compound is a critical building block for introducing hydrophilic PEG spacers with a reactive handle, enabling the modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science who require precise control over molecular architecture and solubility.

Application

• Pharmaceutical Linker: Used as a key intermediate in the synthesis of Antibody-Drug Conjugates (ADCs) and other targeted therapeutics to improve solubility and pharmacokinetics.
• Polymer Modification: Serves as a macro-initiator or functional chain-end for creating amphiphilic block copolymers and PEGylated materials.
• Surface Functionalization: Employed to graft hydrophilic PEG brushes onto nanoparticles, quantum dots, or diagnostic assay surfaces to reduce non-specific binding.
• Proteomics Research: Acts as a reagent for site-specific protein PEGylation (pegylation) to enhance stability and reduce immunogenicity.
• Cross-linking Agent: Utilized in the preparation of hydrogels and biomaterials where a hydrophilic, hydrolytically stable spacer is required.
• Organic Synthesis Intermediate: Provides a versatile handle for nucleophilic substitution reactions to attach various functional groups (amines, azides, thiols) via the bromide terminus.

Basic Information

Product Name	m-Peg6-Bromide
CAS No.	125562-29-0
Molecular Formula	C13H27BrO6
Molecular Weight	359.26 g/mol
Synonyms	1-Bromo-2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethane; 2,5,8,11,14,17-Hexaoxanonadecane, 19-bromo-18-methoxy-; mPEG6-Br; Methoxy-PEG6-bromide; Bromo-PEG6-OMe; α-Methoxy-ω-bromo hexaethylene glycol; Br-PEG6-OMe; PEG6 monomethyl ether bromide
EINECS	Contact for details

Quality Control

Our m-Peg6-Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting applications in GMP-compatible synthesis and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.