Description

4-(Bromomethyl)Tetrahydropyran is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its reactive bromomethyl group makes it a valuable precursor for the introduction of the tetrahydropyranyl moiety, a common structural feature in pharmaceuticals and agrochemicals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries engaged in the development of new active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly those containing tetrahydropyran rings, which are prevalent in drugs targeting the central nervous system and infectious diseases.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the tetrahydropyran structure contributes to biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and advanced materials with specific chemical properties.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in various palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, to form carbon-carbon bonds.
• Protecting Group Chemistry: The bromomethyl group can be further functionalized to create novel protecting groups for alcohols and other sensitive functional groups during multi-step syntheses.

Basic Information

Product Name	4-(Bromomethyl)Tetrahydropyran
CAS No.	125552-89-8
Molecular Formula	C6H11BrO
Molecular Weight	179.06 g/mol
Synonyms	4-(Bromomethyl)oxane; Tetrahydropyran-4-ylmethyl bromide; 4-(Bromomethyl)tetrahydropyran; 4-Bromomethyltetrahydropyran; Oxan-4-ylmethyl bromide; 4-(Bromomethyl)tetrahydro-2H-pyran; THP-4-ylmethyl bromide
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)Tetrahydropyran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.