Description

2-tert-Butyldimethylsiloxybut-3-Yne is a specialized organosilicon reagent featuring a protected terminal alkyne functionality. This compound matters as a versatile and critical building block in modern synthetic organic chemistry, enabling the controlled introduction of alkyne groups into complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as Sonogashira coupling and click chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs) via cross-coupling reactions, particularly in oncology and antiviral drug discovery.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the alkyne moiety is integral to biological activity.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of conductive polymers, dendrimers, and other advanced organic materials.
• Bioconjugation & Probe Development: Essential for "click chemistry" applications, including the labeling of biomolecules (proteins, nucleic acids) with fluorescent or affinity tags for diagnostics and research.
• Academic & Industrial R&D: A fundamental reagent in methodological development and complex natural product synthesis within organic chemistry laboratories.
• Liquid Crystal & OLED Precursor: Employed in the synthesis of rigid, conjugated structures for electronic display and lighting technologies.

Basic Information

Product Name	2-tert-Butyldimethylsiloxybut-3-Yne
CAS No.	125494-93-1
Molecular Formula	C10H20OSi
Molecular Weight	184.35 g/mol
Synonyms	3-Butyn-2-ol, 2-(1,1-dimethylethyl)dimethylsilyl ether; 2-(tert-Butyldimethylsilyloxy)-3-butyne; 2-(TBDMSO)-3-butyne; 2-TBDMS-oxy-3-butyne; 2-(tert-Butyldimethylsiloxy)but-3-yne; 2-(tert-Butyldimethylsilyloxy)but-3-yne; 2-TBDMS-but-3-yn-2-ol; 3-Butyn-2-yl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 2-tert-Butyldimethylsiloxybut-3-Yne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.