Description

7-Aminoclonazepam-D4 is a deuterium-labeled analog of the primary metabolite of the benzodiazepine clonazepam. This stable isotope-labeled compound is a critical analytical standard for ensuring accurate quantification in complex biological matrices. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development and validation in pharmacokinetic and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity internal standard for the precise quantification of 7-aminoclonazepam and clonazepam in bioanalytical assays.
• Forensic Toxicology: Essential for confirmatory testing and accurate measurement of benzodiazepine metabolites in urine, blood, and serum samples.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug metabolism and clearance rates in clinical and preclinical research.
• Drug Metabolism and Disposition Research: Used to study the metabolic pathways and stability of clonazepam and related compounds.
• Reference Material for Method Validation: Provides a certified reference point to validate and calibrate analytical instruments and procedures in compliance with GLP guidelines.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of clonazepam-based drug formulations.

Basic Information

Product Name	7-Aminoclonazepam-D4
CAS No.	125070-96-4
Molecular Formula	C15H9D4ClN4O2
Molecular Weight	319.77 g/mol
Synonyms	7-Amino-5-(2-chlorophenyl)-1,3-dihydro-1,4-dideuterio-2H-1,4-benzodiazepin-2-one; 7-Aminoclonazepam-d4; Deuterated 7-Aminoclonazepam; 7-ACLO-d4; 7-Amino Clonazepam D4; 1,4-Dideuterio-7-aminoclonazepam; 7-Amino-5-(o-chlorophenyl)-1,3-dihydro-1,4-dideuterio-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our 7-Aminoclonazepam-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity, and related substance analysis via validated methods such as HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.