Description

4-(2-Pyridyldithio)Butyramidine is a specialized heterobifunctional crosslinking reagent featuring a reactive pyridyldithiol group and an amidine moiety. This compound is critical for creating cleavable, reversible linkages in bioconjugation chemistry, particularly for modifying proteins, peptides, and other biomolecules. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise control over molecular assembly and disassembly.

Application

• Bioconjugation and Protein Modification: Used to introduce reversible disulfide bonds between biomolecules, enabling controlled release or activity modulation.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies, facilitating targeted cancer therapies.
• Surface Immobilization Chemistry: Enables the reversible attachment of proteins or enzymes to solid supports for biosensor and diagnostic assay development.
• Polymer and Material Science: Acts as a crosslinker for synthesizing smart, stimuli-responsive hydrogels and polymeric materials.
• Peptide Synthesis and Modification: Utilized for site-specific labeling or cyclization of peptides via disulfide bond formation.
• Drug Delivery System Fabrication: Incorporated into nanocarriers and liposomes to create redox-sensitive delivery systems that release cargo in specific cellular environments.

Basic Information

Product Name	4-(2-Pyridyldithio)Butyramidine
CAS No.	124985-61-1
Molecular Formula	C9H11N3S2
Molecular Weight	225.33 g/mol
Synonyms	4-(2-Pyridyldithio)butanimidamide; 2-Pyridyldithio Butyramidine; PDB; 4-(Pyridin-2-yldisulfanyl)butanimidamide; 4-(2-PDS)Butyramidine; 4-(2-Pyridyldithio)butyramidine hydrochloride (if applicable); N-(4-Amidinobutyl)-2-pyridyldisulfide; Heterobifunctional Pyridyldithiol Crosslinker
EINECS	Contact for details

Quality Control

Our 4-(2-Pyridyldithio)Butyramidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under inert atmosphere when appropriate to maximize shelf-life stability. Keep container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.