Description

4-Amino-5-(3-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. Pharmaceutical researchers, agrochemical formulators, and specialty chemical manufacturers need this material for its unique triazole-thiol core and fluorinated aromatic moiety, which are key to modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, including kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Used in developing new generations of fungicides, herbicides, and plant growth regulators where the triazole and fluorine groups enhance efficacy.
• Material Science: Serves as a precursor for ligands in catalysis or as a monomer for specialty polymers with tailored properties.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry due to the reactive thiol and amino functional groups.
• Academic & Industrial R&D: A valuable reagent for methodological studies in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	4-Amino-5-(3-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol
CAS No.	124980-06-9
Molecular Formula	C8H7FN4S
Molecular Weight	210.23 g/mol
Synonyms	3-Fluoro-5-(5-mercapto-4H-1,2,4-triazol-4-yl)aniline; 4-Amino-5-(3-fluorophenyl)-4H-1,2,4-triazole-3-thiol; 5-(3-Fluorophenyl)-4H-1,2,4-triazole-3-thiol, 4-amino-; 4-Amino-5-(m-fluorophenyl)-1,2,4-triazole-3-thiol; 3-Fluoro-5-(3-mercapto-1H-1,2,4-triazol-5-yl)aniline; 124980-06-9; 4H-1,2,4-Triazole-3-thiol, 4-amino-5-(3-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4-Amino-5-(3-Fluorophenyl)-4H-1,2,4-Triazole-3-Thiol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be stored away from direct light. For long-term storage, consider keeping the container under an inert atmosphere to minimize potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.