Description

Myristic Acid-[9,10-3H] is a high-specific-activity, tritium-labeled isotopologue of tetradecanoic acid, a key saturated fatty acid. This radiolabeled compound is essential for precise metabolic and pharmacokinetic tracer studies, enabling researchers to track biochemical pathways with high sensitivity. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) specializing in lipid metabolism, drug absorption, and biomarker discovery.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the β-oxidation and incorporation of myristic acid into complex lipids.
• Drug Development & ADME Studies: Critical for Absorption, Distribution, Metabolism, and Excretion (ADME) research of fatty acid-based drug candidates or prodrugs.
• Biochemical Assay Development: Serves as a standard or substrate in enzymatic assays for fatty acid metabolism, such as those involving acyl-CoA synthetases.
• Lipidomics Research: Enables the sensitive detection and quantification of myristoylated proteins and lipids in cellular systems.
• Membrane Biology Studies: Investigates the role of myristic acid in protein anchoring (myristoylation) and membrane fluidity.
• Autoradiography & Imaging: Suitable for use in tissue distribution studies via autoradiographic techniques.

Basic Information

Product Name	Myristic Acid-[9,10-3H]
CAS No.	124511-74-6
Molecular Formula	C14H26*O2 (* denotes 3H)
Molecular Weight	~230.36 g/mol (varies with specific activity)
Synonyms	Tetradecanoic Acid-[9,10-3H]; [9,10-3H]-Myristic Acid; Tritiated Myristic Acid; Radiolabeled Myristic Acid; n-Tetradecanoic Acid (tritiated); C14:0 Fatty Acid (tritiated); FA 14:0 (tritiated); [9,10-3H]Tetradecanoic Acid
EINECS	Contact for details

Quality Control

Every batch of Myristic Acid-[9,10-3H] is manufactured and analyzed under strict quality systems to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for research. Comprehensive Certificates of Analysis (COA) are provided, detailing results for key parameters including assay by HPLC, radiochemical purity by radio-HPLC or TLC, and specific activity (typically expressed in Ci/mmol or GBq/mmol). Our quality commitment aligns with the needs of GLP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent (e.g., toluene, ethanol) as specified. Due to its nature as a highly volatile and easily oxidized (store under inert atmosphere) radiolabeled compound, it is recommended to store under an inert atmosphere (argon or nitrogen) when possible and minimize freeze-thaw cycles. Always follow local regulations for the storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Specific Activity	10-100 Ci/mmol (Contact for exact value)
Radiochemical Purity (Radiometric HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Toluene, Ethanol, or as specified
Concentration	1 mCi/mL (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.