Description

Enadoline is a potent and selective κ-opioid receptor (KOR) agonist, a compound of significant interest in advanced pharmacological research. Its primary value lies in its distinct mechanism of action, which is being studied for its potential to modulate pain perception and central nervous system activity without the typical mu-opioid side effects. This makes it a critical reference standard and research chemical for pharmaceutical R&D teams, neuroscientists, and analytical laboratories. The compound is essential for developing novel therapeutic agents and for conducting high-precision bioanalytical studies.

Application

• Pharmacological Research: Used as a selective κ-opioid receptor agonist to study receptor binding, signal transduction, and downstream physiological effects.
• Neuroscience Studies: A vital tool for investigating the role of the κ-opioid system in pain modulation, mood disorders, and addiction pathways.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and GC-MS analyses.
• Drug Discovery & Development: Employed in preclinical studies to explore the therapeutic potential of KOR agonists for treating chronic pain, pruritus, and other CNS-related conditions.
• Biochemical Assays: Utilized in in vitro and ex vivo assays to screen for receptor activity and to evaluate the efficacy and selectivity of new chemical entities.

Basic Information

Product Name	Enadoline
CAS No.	124378-77-4
Molecular Formula	C24H30N2O3
Molecular Weight	394.51 g/mol
Synonyms	CI-977; (5R,6S,8S)-6-(2,3-Dichlorophenyl)-1-oxa-2,7-diazaspiro[4.5]decan-8-ol; Enadoline hydrochloride; U-62066E; Spiradoline mesylate (related salt form)
EINECS	Contact for details

Quality Control

Every batch of Enadoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including assay (HPLC), related substances, residual solvents, and specific identification tests. Our quality commitment supports compliance with the rigorous standards required for pharmaceutical reference materials and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.