Description

5-Sulfamoyl-o-Anisic Acid-D3 is a deuterated derivative of 5-sulfamoyl-o-anisic acid, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in regulated environments. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the accurate quantification of 5-sulfamoyl-o-anisic acid and related compounds in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies, enabling precise tracking of parent drug and metabolite levels during preclinical and clinical development.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Metabolite Profiling: Aids in the identification and structural elucidation of drug metabolites by providing a stable isotopic reference point.
• Quality Control in API Manufacturing: Employed in analytical laboratories to monitor process-related impurities and ensure the quality of active pharmaceutical ingredients (APIs).
• Forensic and Clinical Toxicology: Facilitates the precise measurement of specific analytes in forensic investigations or therapeutic drug monitoring programs.

Basic Information

Product Name	5-Sulfamoyl-o-Anisic Acid-D3
CAS No.	123958-85-0
Molecular Formula	C8H4D3NO5S
Molecular Weight	234.22 g/mol (approximate)
Synonyms	2-Methoxy-5-sulfamoylbenzoic-2,4,6-D3 acid; 2-Methoxy-5-sulfamoylbenzoic acid-d3; 5-(Aminosulfonyl)-2-methoxybenzoic-2,4,6-D3 acid; Deuterated 5-Sulfamoylanisic Acid; 5-Sulfamoyl-2-methoxybenzoic acid-d3; [2,4,6-2H3]-5-Sulfamoyl-o-anisic acid; o-Anisic acid, 5-sulfamoyl-, 2,4,6-trideuterio-
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch of 5-Sulfamoyl-o-Anisic Acid-D3 is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-content), chemical purity, and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.